Endocrine Abstracts

In type 1 diabetes mellitus, tight glycaemic control is required to attenuate chronic complications and often requires daily injectable insulin therapy, which can result in non-compliance because of patient discomfort. As a result of this, some studies are concerned with optional routes of insulin administration. In our laboratory, we have developed amidated pectin (polygalacturonic acid) hydrogel beads for oral insulin administration. The aim of present was to investigate whe...

Chloroquine (CHQ) the most frequently used drug for falciparum malaria in sub-Saharan Africa countries evokes adverse effects on glucose homeostasis and kidney function in African children. The complications can partly be ascribed to transiently high plasma CHQ concentrations following oral administration and/or malaria parasites. We have, however, reported that topical application of the pectin CHQ matrix patch releases CHQ into the bloodstream. Accordingly, the curr...

We investigated effects of ethanolic Persea americana Mill. (‘Avocado’) leaf extracts (PAE) on blood glucose and kidney function in rats. Extracts of the plant have been employed to treat hypertension and diabetes mellitus. Oral glucose tolerance tests (OGTT) were conducted in fasted non-diabetic and STZ-diabetic rats following a glucose load (0.86 g/kg, p.o.), followed by various PAE doses (60, 120 and 240 mg/kg). Rats treated with deionised water or standard...